Cubicle Dilemma: When Do You Say Something?

It happens. Coughers. Throat clearers. Grunters. Snifflers. We all have coworkers who do things that annoy us. Particularly this time of year, when people often get a little sick as we transition from winter to spring. But sitting next to someone who constantly clears their throat of coughs can be beyond annoying. That presents the problem of how to handle that annoyance. Do you say something? If so, what?